Aphanamgrandiol A, a new triterpenoid with a unique carbon skeleton from Aphanamixis grandifolia

Fitoterapia. 2013 Apr:86:217-21. doi: 10.1016/j.fitote.2013.02.011. Epub 2013 Feb 26.

Abstract

Aphanamgrandiol A (1), a novel triterpenoid with a bicyclo[3,2,1]octane ring skeleton produced by 2,3-ring opening and 2,6-ring closure, was isolated from the stems of Aphanamixis grandifolia. The structures were established on the basis of extensive spectroscopic methods, including 1D and 2D NMR techniques, and determined unambiguously by X-ray crystal diffraction. Aphanamgrandiol A showed moderate cytotoxicities against MCG-803, SKOV-3, HCT116 and HepG2 cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Carbon / chemistry
  • HCT116 Cells
  • Hep G2 Cells
  • Humans
  • Meliaceae / chemistry*
  • Molecular Structure
  • Neoplasms / drug therapy
  • Phytotherapy
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Triterpenes / therapeutic use

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Triterpenes
  • aphanamgrandiol A
  • Carbon