Abstract
Reactions of hydrazonoyl halides with cyanoacetic hydrazide and its N-arylidene derivatives proceeded site-selectively and afforded the respective pyrazolo[3,4-d]pyridazine and aldehyde N-(1-aryl-3-acetyl-4-cyanopyrazol-5-yl)hydrazone derivatives. The structures of the products were elucidated on the basis of their spectral and elemental analyses. The anti-aggressive activity of the compounds prepared was screened.
MeSH terms
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Aggression / drug effects*
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Animals
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Disease Models, Animal
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Hydrazones / chemical synthesis
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Hydrazones / chemistry
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Hydrazones / pharmacology*
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Male
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Mice
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Pyridazines / chemical synthesis
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Pyridazines / chemistry
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Pyridazines / pharmacology*
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Spectrum Analysis
Substances
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Hydrazones
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Pyrazoles
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Pyridazines
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pyrazolo(3,4-d)pyridazin