Abstract
A robust and efficient protocol for the introduction of the dioxolanylethyl moiety onto various aryl and heteroaryl halides has been developed, providing cross-coupling yields up to 93%. Copper-catalyzed borylation of 2-(2-bromoethyl)-1,3-dioxolane with bis(pinacolato)diboron followed by treatment with potassium bifluoride provides the key organotrifluoroborate reagent.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Borates / chemistry*
-
Catalysis
-
Combinatorial Chemistry Techniques
-
Copper / chemistry
-
Dioxolanes / chemical synthesis*
-
Dioxolanes / chemistry
-
Hydrocarbons, Chlorinated / chemical synthesis*
-
Hydrocarbons, Chlorinated / chemistry
-
Molecular Structure
-
Potassium / chemistry*
Substances
-
Borates
-
Dioxolanes
-
Hydrocarbons, Chlorinated
-
Copper
-
Potassium