Comparative metabolite profiling and chemical study of Ramalina siliquosa complex using LC-ESI-MS/MS approach

Delphine Parrot; Saleem Jan; Nicolas Baert; Sylvain Guyot; Sophie Tomasi

doi:10.1016/j.phytochem.2013.02.002

Comparative metabolite profiling and chemical study of Ramalina siliquosa complex using LC-ESI-MS/MS approach

Phytochemistry. 2013 May:89:114-24. doi: 10.1016/j.phytochem.2013.02.002. Epub 2013 Mar 13.

Authors

Delphine Parrot¹, Saleem Jan, Nicolas Baert, Sylvain Guyot, Sophie Tomasi

Affiliation

¹ Equipe PNSCM Produits naturels - Synthèses - Chimie Médicinale, UMR CNRS 6226, Institut des Sciences chimiques de Rennes, UFR Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, Université Européenne de Bretagne, 2 Avenue du Pr. Léon Bernard, F-35043 Rennes, France.

PMID: 23489575
DOI: 10.1016/j.phytochem.2013.02.002

Abstract

A chemical study of the lichen Ramalina siliquosa complex found in Brittany was conducted. Eight chemotypes were considered and their chemical composition was elucidated for the first time by LC-MS analysis. Ten main compounds were identified: conhypoprotocetraric acid (1), salazinic acid (2), peristictic acid (3), cryptostictic acid (4), protocetraric acid (5), stictic acid (6), norstictic acid (7), hypoprotocetraric acid (8), 4-O-demethylbarbatic acid (9), (+)-usnic acid (10) and 22 minor compounds were reported. The MS/MS fragmentation patterns of each compound of R. siliquosa complex were determined and proposed.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Ascomycota / chemistry*
Ascomycota / metabolism*
Chromatography, Liquid
Metabolomics*
Spectrometry, Mass, Electrospray Ionization
Tandem Mass Spectrometry