Abstract
A phytochemical study of Cryptocarya maclurei led to isolation of five flavanones, cryptogiones G-H, and a polyketide, cryptomaclurone. The structures of the isolates were elucidated by analysis of the 1D and 2D NMR spectroscopic data, and their absolute configurations were determined by CD methods. A putative biosynthetic pathway to them is proposed. Cytotoxicity of these compounds evaluated against KB, SGC-7901 and SW 1116 cancer cell lines, with only cryptomaclurone exhibiting moderate cytotoxicity (IC50 28.2, 28.4 and 16.4μM, respectively).
Copyright © 2013 Elsevier Ltd. All rights reserved.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cryptocarya / chemistry*
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Cytotoxins / chemistry
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Cytotoxins / isolation & purification*
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Cytotoxins / pharmacology*
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Flavanones / chemistry
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Flavanones / isolation & purification
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Flavanones / pharmacology
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Humans
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Inhibitory Concentration 50
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KB Cells
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Molecular Conformation
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Plant Stems / chemistry
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Structure-Activity Relationship
Substances
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Antineoplastic Agents, Phytogenic
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Cytotoxins
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Flavanones