Abasic oligodeoxyribonucleoside phosphorothioates: synthesis and evaluation as anti-HIV-1 agents

R P Iyer; B Uznanski; J Boal; C Storm; W Egan; M Matsukura; S Broder; G Zon; A Wilk; M Koziolkiewicz

doi:10.1093/nar/18.10.2855

Abasic oligodeoxyribonucleoside phosphorothioates: synthesis and evaluation as anti-HIV-1 agents

Nucleic Acids Res. 1990 May 25;18(10):2855-9. doi: 10.1093/nar/18.10.2855.

Authors

R P Iyer¹, B Uznanski, J Boal, C Storm, W Egan, M Matsukura, S Broder, G Zon, A Wilk, M Koziolkiewicz, et al.

Affiliation

¹ Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD.

Abstract

The syntheses and anti-HIV-1 evaluations of two, abasic oligodeoxyribonucleotide phosphorothioate analogs, d[Cps(Eps)26C] and d[Cps(Vps)26C] (where E and V derive from 1,2-dideoxy-D-ribofuranose and (+/-)-butane 1, 3-diol, respectively), are described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology
Cell Line
Chemical Phenomena
Chemistry
Cytopathogenic Effect, Viral / drug effects
HIV-1 / drug effects*
Molecular Structure
Oligodeoxyribonucleotides / chemical synthesis*
Oligodeoxyribonucleotides / pharmacology
Thionucleotides / chemical synthesis*
Thionucleotides / pharmacology

Substances

Antiviral Agents
Oligodeoxyribonucleotides
Thionucleotides