"Clickable" hydrosoluble PEGylated cryptophane as a universal platform for 129Xe magnetic resonance imaging biosensors

Léa Delacour; Naoko Kotera; Ténin Traoré; Sébastien Garcia-Argote; Céline Puente; François Leteurtre; Edmond Gravel; Nawal Tassali; Céline Boutin; Estelle Léonce; Yves Boulard; Patrick Berthault; Bernard Rousseau

doi:10.1002/chem.201204218

"Clickable" hydrosoluble PEGylated cryptophane as a universal platform for 129Xe magnetic resonance imaging biosensors

Chemistry. 2013 May 3;19(19):6089-93. doi: 10.1002/chem.201204218. Epub 2013 Mar 13.

Authors

Léa Delacour¹, Naoko Kotera, Ténin Traoré, Sébastien Garcia-Argote, Céline Puente, François Leteurtre, Edmond Gravel, Nawal Tassali, Céline Boutin, Estelle Léonce, Yves Boulard, Patrick Berthault, Bernard Rousseau

Affiliation

¹ iBiTecS, Service de Chimie Bioorganique et de Marquage (SCBM), CEA, 91191 Gif-sur-Yvette, France.

PMID: 23494947
DOI: 10.1002/chem.201204218

Abstract

We describe the synthesis of a highly water-soluble cryptophane 1 that can be seen as a universal platform for the construction of (129)Xe magnetic resonance imaging (MRI)-based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon-encapsulation properties. In addition, 1 is nontoxic at the concentrations typically used for hyperpolarized (129)Xe MRI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques / methods*
Click Chemistry
Magnetic Resonance Spectroscopy / methods*
Polycyclic Compounds / chemistry*
Water
Xenon / chemistry*

Substances

Polycyclic Compounds
cryptophane
Water
Xenon