Angiographic findings in 2 children with cerebral paragonimiasis with hemorrhage

J Neurosurg Pediatr. 2013 May;11(5):564-7. doi: 10.3171/2013.1.PEDS12475. Epub 2013 Mar 15.

Abstract

Hemorrhagic events associated with cerebral paragonimiasis are not rare, especially in children and adolescents; however, angiographic evidence of cerebrovascular involvement has not been reported. The authors describe angiographic abnormalities of the cerebral arteries seen in 2 children in whom cerebral paragonimiasis was associated with hemorrhagic stroke. The patients presented with acute intracerebral and subarachnoid hemorrhage. Angiography revealed a beaded appearance and long segmental narrowing of arteries, consistent with arteritis. In both patients, involved vessels were seen in the area of the hemorrhage. The vascular changes and the hemorrhage, together with new lesions that developed close to the hemorrhage and improved after praziquantel treatment, were attributed to paragonimiasis. Further study of the frequency and mechanism of hemorrhagic cerebrovascular complications associated with cerebral paragonimiasis is needed.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Anthelmintics / therapeutic use
  • Brain / parasitology*
  • Brain / pathology
  • Central Nervous System Helminthiasis / complications
  • Central Nervous System Helminthiasis / diagnosis
  • Central Nervous System Helminthiasis / diagnostic imaging*
  • Cerebral Angiography*
  • Cerebral Arteries / diagnostic imaging*
  • Cerebral Arteries / pathology
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Intracranial Hemorrhages / diagnostic imaging*
  • Intracranial Hemorrhages / parasitology*
  • Magnetic Resonance Imaging
  • Male
  • Paragonimiasis / diagnostic imaging*
  • Paragonimus / immunology
  • Paragonimus / isolation & purification*
  • Praziquantel / therapeutic use
  • Retreatment
  • Subarachnoid Hemorrhage / diagnostic imaging
  • Subarachnoid Hemorrhage / parasitology
  • Tomography, X-Ray Computed*
  • Treatment Outcome

Substances

  • Anthelmintics
  • Immunoglobulin G
  • Praziquantel