Phase transfer-catalyzed synthesis of highly acrylated hyaluronan

Carbohydr Polym. 2013 Apr 2;93(2):438-41. doi: 10.1016/j.carbpol.2012.12.056. Epub 2012 Dec 27.

Abstract

Glycosaminoglycans and its derivatives have gained increasing attention for the fabrication of hydrogels usable in biomedicine. Starting from high molecular weight hyaluronan, a natural glycosaminoglycan that forms a mayor component of the native extracellular matrix, we present an efficient phase-transfer-based synthesis for low molecular weight hyaluronan acrylates with a tailored degree of substitution (DS) ranging up to DS values of 1.7. The ability of these compounds to form dimensionally stable hydrogels was proven using different photo-initiator systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylates / chemistry*
  • Cross-Linking Reagents / chemistry
  • Hyaluronic Acid / chemical synthesis*
  • Hyaluronic Acid / chemistry
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemical synthesis*
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry
  • Light
  • Materials Testing
  • Molecular Weight
  • Phase Transition
  • Polysaccharides, Bacterial / chemistry
  • Streptococcus / chemistry

Substances

  • Acrylates
  • Cross-Linking Reagents
  • Polysaccharides, Bacterial
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • acryloyl chloride
  • Hyaluronic Acid