Enzyme-responsive copper sulphide nanoparticles for combined photoacoustic imaging, tumor-selective chemotherapy and photothermal therapy

Zhengbao Zha; Shuhai Zhang; Zijian Deng; Yanyan Li; Changhui Li; Zhifei Dai

doi:10.1039/c3cc40608c

Enzyme-responsive copper sulphide nanoparticles for combined photoacoustic imaging, tumor-selective chemotherapy and photothermal therapy

Chem Commun (Camb). 2013 Apr 28;49(33):3455-7. doi: 10.1039/c3cc40608c.

Authors

Zhengbao Zha¹, Shuhai Zhang, Zijian Deng, Yanyan Li, Changhui Li, Zhifei Dai

Affiliation

¹ Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

PMID: 23507786
DOI: 10.1039/c3cc40608c

Abstract

Gelatin-stabilized copper sulphide nanoparticles with conjugated doxorubicin have been developed for combined photoacoustic imaging, enzyme-responsive drug release and photothermal therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / chemistry*
Antibiotics, Antineoplastic / therapeutic use
Antibiotics, Antineoplastic / toxicity
Apoptosis / drug effects
Copper / chemistry*
Doxorubicin / chemistry*
Doxorubicin / therapeutic use
Doxorubicin / toxicity
Gelatin / chemistry*
Gelatinases / metabolism*
HeLa Cells
Humans
Infrared Rays
Metal Nanoparticles / chemistry*
Neoplasms / diagnosis
Neoplasms / therapy
Photoacoustic Techniques
Phototherapy

Substances

Antibiotics, Antineoplastic
Copper
Doxorubicin
Gelatin
Gelatinases
cupric sulfide