Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactions

Chemistry. 2013 Apr 26;19(18):5546-50. doi: 10.1002/chem.201204098. Epub 2013 Mar 18.

Abstract

Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenylmethoxycarbonyl).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Benzamides / chemical synthesis*
  • Benzamides / chemistry
  • Chemistry, Organic / methods*
  • Fluorenes / chemistry*
  • Molecular Structure
  • Protein Structure, Secondary

Substances

  • 9-fluorenylmethoxycarbonyl
  • Benzamides
  • Fluorenes