Placetins, platelet aggregation inhibitors from Streptomyces sp. Q-1043. I. Fermentation, isolation and biological properties

T Ozasa; K Suzuki; T Yamada; K Suzaki; C Nohara; M Kobori; T Saito

doi:10.7164/antibiotics.43.331

Placetins, platelet aggregation inhibitors from Streptomyces sp. Q-1043. I. Fermentation, isolation and biological properties

J Antibiot (Tokyo). 1990 Apr;43(4):331-5. doi: 10.7164/antibiotics.43.331.

Authors

T Ozasa¹, K Suzuki, T Yamada, K Suzaki, C Nohara, M Kobori, T Saito

Affiliation

¹ Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.

PMID: 2351609
DOI: 10.7164/antibiotics.43.331

Abstract

Placetins, platelet aggregation inhibitors were obtained from the culture broth of Streptomyces sp. Q-1043. These were designated placetins A, A1, B and B1, respectively. Placetins A and B showed strong cytotoxicities against P388, L1210 and HeLa cells.

MeSH terms

Animals
Bacteria / drug effects
Biological Factors / isolation & purification*
Biological Factors / pharmacology
Fermentation
HeLa Cells
Humans
Leukemia L1210
Leukemia P388
Platelet Aggregation / drug effects*
Platelet Aggregation Inhibitors / isolation & purification*
Platelet Aggregation Inhibitors / pharmacology
Streptomyces / metabolism*
Tumor Cells, Cultured

Substances

Biological Factors
Platelet Aggregation Inhibitors