Caveolin-1 as a promoter of tumour spreading: when, how, where and why

J Cell Mol Med. 2013 Mar;17(3):325-36. doi: 10.1111/jcmm.12030. Epub 2013 Mar 23.

Abstract

Caveolae are non-clathrin invaginations of the plasma membrane in most cell types; they are involved in signalling functions and molecule trafficking, thus modulating several biological functions, including cell growth, apoptosis and angiogenesis. The major structural protein in caveolae is caveolin-1, which is known to act as a key regulator in cancer onset and progression through its role as a tumour suppressor. Caveolin-1 can also promote cell proliferation, survival and metastasis as well as chemo- and radioresistance. Here, we discuss recent findings and novel concepts that support a role for caveolin-1 in cancer development and its distant spreading. We also address the potential application of caveolin-1 in tumour therapy and diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caveolin 1 / metabolism*
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology*
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Signal Transduction*

Substances

  • Caveolin 1