Light chain proximal tubulopathy without crystals in a case of Burkitt lymphoma presenting with acute kidney injury

Am J Kidney Dis. 2013 Sep;62(3):638-41. doi: 10.1053/j.ajkd.2013.01.026. Epub 2013 Mar 22.

Abstract

Acute kidney injury is a common manifestation of malignancies, either directly by the tumor or indirectly from anticancer therapy. The pathologic correlates of acute kidney injury in malignancies are many and can be diagnosed conclusively using kidney biopsy. We report a rare case of a patient with light chain proximal tubulopathy without crystals who presented with acute kidney injury. Kidney biopsy showed proximal tubulopathy without crystals with λ light chain restriction. Detailed investigations lead to a diagnosis of Burkitt lymphoma with surface λ light chain restriction.

Keywords: Acute kidney injury; Burkitt leukemia; kidney biopsy; light chain proximal tubulopathy; light chain proximal tubulopathy without crystals.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / complications
  • Acute Kidney Injury / diagnosis*
  • Acute Kidney Injury / immunology
  • Adult
  • Burkitt Lymphoma / complications
  • Burkitt Lymphoma / diagnosis*
  • Burkitt Lymphoma / immunology
  • Crystallization
  • Diagnosis, Differential
  • Humans
  • Immunoglobulin lambda-Chains / chemistry
  • Kidney Tubules, Proximal / immunology
  • Kidney Tubules, Proximal / pathology*
  • Male

Substances

  • Immunoglobulin lambda-Chains