Branchial cleft anomalies are the second most common congenital head and neck lesions to arise in the neck.Second branchial cleft cyst typically presents as a nontender, painless, smooth, and round neck mass located along the upper third of the anterior border of the sternocleidomastoid muscle which may acutely increase in size after an upper respiratory infection.The aim of this article was to illustrate a case of a giant second branchial cyst 8 cm in diameter that was surgically treated at the Department of Maxillo-Facial Surgery of Sant'Andrea Hospital in Rome.