Efficacy of ranolazine in a patient with idiopathic dilated cardiomyopathy and electrical storm

Drug Discov Ther. 2013 Feb;7(1):43-5. doi: 10.5582/ddt.2013.v7.1.43.

Abstract

A case of idiopathic dilated cardiomyopathy with an arrhythmic storm refractory to the usual antiarrhythmic therapy will be reported. The idiopathic structural heart disease of the patient is a vulnerable anatomic substrate in itself, for electrical instability and reentry mechanism, because of heterogeneous areas of scarred myocardium and low left ventricle ejection fraction. In this case, the ranolazine administration was safe and effective for the prevention of further electrical storms.

Publication types

  • Case Reports

MeSH terms

  • Acetanilides / administration & dosage
  • Acetanilides / therapeutic use*
  • Aged
  • Anti-Arrhythmia Agents / administration & dosage
  • Anti-Arrhythmia Agents / therapeutic use*
  • Cardiomyopathy, Dilated / complications
  • Cardiomyopathy, Dilated / diagnosis
  • Cardiomyopathy, Dilated / drug therapy*
  • Defibrillators, Implantable
  • Electrocardiography
  • Heart Rate / drug effects
  • Humans
  • Male
  • Piperazines / administration & dosage
  • Piperazines / therapeutic use*
  • Ranolazine
  • Tachycardia, Ventricular / complications
  • Tachycardia, Ventricular / diagnosis
  • Tachycardia, Ventricular / drug therapy*
  • Treatment Outcome
  • Ventricular Dysfunction, Left / complications
  • Ventricular Dysfunction, Left / diagnosis
  • Ventricular Dysfunction, Left / drug therapy

Substances

  • Acetanilides
  • Anti-Arrhythmia Agents
  • Piperazines
  • Ranolazine