Keratin Expression in Mammary Paget's Disease in situ with Intraductal Invasion

Ichiro Kurokawa; Sayaka Furukawa; Masahiro Kishimoto; Ayako Kakuno; Airo Tsubura

doi:10.1159/000341663

Keratin Expression in Mammary Paget's Disease in situ with Intraductal Invasion

Case Rep Oncol. 2012 May;5(2):400-3. doi: 10.1159/000341663. Epub 2012 Jul 24.

Authors

Ichiro Kurokawa¹, Sayaka Furukawa, Masahiro Kishimoto, Ayako Kakuno, Airo Tsubura

Affiliation

¹ Department of Dermatology, Meiwa Hospital, Nishinomiya, Osaka, Japan.

Abstract

We performed immunohistochemical studies of epithelial keratins in intraductal carcinoma in situ (IDCIS) in mammary Paget's disease (MPD). K7, K8 and K18 were expressed in IDCIS in MPD. However, K19 was not expressed in IDCIS in MPD. Interestingly, K17 was expressed in some tumor cells in IDCIS. K17, a hyperproliferative keratin, may suggest ductal invasion and poor prognosis in MPD.

Keywords: Intraductal carcinoma; Keratins; Mammary Paget's disease.

Publication types

Case Reports