Influence of body mass index (BMI) on functional improvements at 3 years following total knee replacement: a retrospective cohort study

PLoS One. 2013;8(3):e59079. doi: 10.1371/journal.pone.0059079. Epub 2013 Mar 19.

Abstract

Background: The number of patients presenting for total knee replacement who are classified as obese is increasing. The functional benefits of performing TKR in these patients are unclear.

Aim: To assess the influence pre-operative body mass index has upon knee specific function, general health status and patient satisfaction at 3 years following total knee replacement.

Design: Retrospective comparative cohort study using prospectively collected data from an institutional arthroplasty register.

Methods: 1367 patients were assessed using the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and Medical Outcomes Trust Short Form-36 (SF-36) scores supplemented by a validated measure of satisfaction pre-operatively and subsequently at 1,2 and 3 year post-operatively. Comparisons were made by dividing the cohort into 4 groups based on body mass index (BMI) 18.5-25.0 kg/m(2) (n = 253);>25.0-30.0 kg/m(2) (n = 559);>30.0-35.0 kg/m(2) (n = 373);>35.0 kg/m(2) (n = 182).

Results: Despite lower pre-operative, 1 and 3 year WOMAC and SF-36 scores patients with the highest BMIs >35.0 kg/m(2) experienced similar improvements to patients with a 'normal' BMI (18.5-25.0 kg/m(2)) at 1 year (Difference in WOMAC improvement = 0.0 (95%CI -5.2 to 5.2), p = 1.00) and this improvement was sustained at up to 3 years (Difference in 1 year to 3 year improvement = 2.2 (95%CI: -2.1 to 6.5), p = 1.00). This effect was also observed for the SF-36 mental and physical component scores. Despite equivalent functional improvements levels of satisfaction in the >35.0 kg/m(2) group were lower than for any other BMI group (>35.0 kg/m(2) = 84.6% satisfied versus 18.5-5.0 kg/m(2) = 93.3% satisfied,p = 0.01) as was the proportion of patients who stated they would have the operation again (>35.0 kg/m(2) = 69.6% versus 18.5-25.0 kg/m(2) = 82.2%,p = 0.01).

Conclusion: Obese and morbidly obese patients gain as much functional benefit from total knee replacement as patients with lesser body mass indexes. This benefit is maintained for up to 3 years following surgery. However, these patients are less satisfied with their knee replacement and almost a third would not have the operation again.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Arthroplasty, Replacement, Knee / rehabilitation*
  • Body Mass Index*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obesity
  • Patient Satisfaction
  • Quality of Life
  • Retrospective Studies

Grants and funding

This work was supported by a research grant from Depuy Orthopaedics Inc (Marwah, Indiana, USA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.