Seroprevalence of varicella-zoster virus in the prevaccine era: a population-based study in Izmir, Turkey

J Infect Public Health. 2013 Apr;6(2):115-9. doi: 10.1016/j.jiph.2012.10.003. Epub 2013 Jan 1.

Abstract

Purpose: To determine the population-based seroprevalence of varicella zoster virus (VZV) and related risk factors in Izmir.

Materials and methods: A population-based household survey was conducted. A representative sample of the population older than 15 years of age was selected using multistage random sampling. A total of 2136 healthy persons participated in this cross-sectional study. The participants completed a questionnaire designed to collect data related to socio-demographic characteristics and risk factors. Blood samples were collected, and VZV-specific IgG was measured using an ELISA.

Results: In total, 94.3% of individuals were seropositive for VZV. The difference between VZV seroprevalence in urban and rural populations was significant (OR: 2.6 (95% CI, 1.7-3.8)). No statistically significant differences in seropositivity were observed with respect to other sociodemographic characteristics.

Conclusion: A large proportion of the participants were found to be immune to VZV.

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Antibodies, Viral / blood*
  • Chickenpox / epidemiology*
  • Chickenpox / immunology
  • Chickenpox / prevention & control
  • Cross-Sectional Studies
  • Female
  • Herpesvirus 3, Human / immunology*
  • Humans
  • Immunoglobulin G / blood
  • Male
  • Risk Factors
  • Rural Population / statistics & numerical data*
  • Seroepidemiologic Studies
  • Surveys and Questionnaires
  • Turkey / epidemiology
  • Urban Population / statistics & numerical data*
  • Young Adult

Substances

  • Antibodies, Viral
  • Immunoglobulin G