The impact of cognitive behavioral therapy on IL-6 levels in unmedicated women experiencing the first episode of depression: a pilot study

Marta Gazal; Luciano D Souza; Briane A Fucolo; Carolina D Wiener; Ricardo A Silva; Ricardo T Pinheiro; Karen Jansen; Gabriele Ghislene; Jean P Oses; Manuella P Kaster

doi:10.1016/j.psychres.2013.03.002

The impact of cognitive behavioral therapy on IL-6 levels in unmedicated women experiencing the first episode of depression: a pilot study

Psychiatry Res. 2013 Oct 30;209(3):742-5. doi: 10.1016/j.psychres.2013.03.002. Epub 2013 Mar 27.

Authors

Marta Gazal¹, Luciano D Souza, Briane A Fucolo, Carolina D Wiener, Ricardo A Silva, Ricardo T Pinheiro, Karen Jansen, Gabriele Ghislene, Jean P Oses, Manuella P Kaster

Affiliation

¹ Universidade Católica de Pelotas (UCPel), Department of Life and Health Sciences, Pelotas, Rio Grande do Sul, Brazil.

PMID: 23541242
DOI: 10.1016/j.psychres.2013.03.002

Abstract

A group of 11 women (18-29 years old) in the first episode of depression was evaluated before and after cognitive behavioral therapy (CBT). Depressive scores, assessed by Hamilton Rating Scale (HRSD), and serum IL-6 levels significantly decreased after the seventh session. These results suggest that CBT reduced both depressive symptoms and the inflammatory state in women.

Keywords: Cognitive behavioral therapy; Depression; Interleukin-6.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Alkaloids
Cognitive Behavioral Therapy / methods*
Depression / blood*
Depression / rehabilitation*
Female
Humans
Interleukin-6 / blood*
Pilot Projects
Psychiatric Status Rating Scales
Regression Analysis
Young Adult

Substances

Alkaloids
Interleukin-6
Wilcox compound