Hydrophilic chlorin-conjugated magnetic nanoparticles--potential anticancer agent for the treatment of melanoma by PDT

Bioorg Med Chem Lett. 2013 May 1;23(9):2486-90. doi: 10.1016/j.bmcl.2013.03.039. Epub 2013 Mar 20.

Abstract

This Letter reports the synthesis and the characterization of two new water-stable and soluble photosensitizer-conjugated magnetic nanoparticles (PS-MNPs) composed of an iron oxide magnetic core coated with a biocompatible dextran shell bearing polyaminated chlorin p6. Designed to improve cancer cell targeting, these photosensitizers were assayed for their antitumour activity against two variants of B16 mouse melanoma cell line (B16F10 and B16G4F, with or without melanin, respectively). Cell viability measurements demonstrated that PS-MNPs were more phototoxic than PEI-chlorin p6 making these photosensitizers promising for further in vitro and in vivo investigations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / therapeutic use
  • Antineoplastic Agents / toxicity
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Hydrophobic and Hydrophilic Interactions
  • Light
  • Magnetite Nanoparticles / chemistry*
  • Magnetite Nanoparticles / ultrastructure
  • Melanoma, Experimental / drug therapy
  • Mice
  • Photochemotherapy
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / therapeutic use
  • Photosensitizing Agents / toxicity
  • Porphyrins / chemistry*
  • Temperature

Substances

  • Antineoplastic Agents
  • Magnetite Nanoparticles
  • Photosensitizing Agents
  • Porphyrins
  • chlorin