Abstract
Arsenic trioxide (As2O3) is an important environmental toxin. In this study, the effect of resveratrol on As2O3-induced lung injury in rats is evaluated. The results showed that pre-treatment with resveratrol protected As2O3-induced lung injury by the maintenance of glutathione redox system and decrease in arsenic retention. These suggest supplement with resveratrol may alleviate lung injury in the individuals with chronic exposure to arsenic.
Copyright © 2013 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / administration & dosage*
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Arsenic / metabolism
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Arsenic Trioxide
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Arsenicals / administration & dosage*
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Arsenicals / pharmacokinetics
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Environmental Pollutants / administration & dosage
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Environmental Pollutants / pharmacokinetics
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Environmental Pollutants / toxicity
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Glutathione / metabolism
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Lung / drug effects*
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Lung / metabolism
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Lung / pathology
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Male
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Oxidative Stress / drug effects
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Oxides / administration & dosage*
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Oxides / pharmacokinetics
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Oxides / toxicity
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Rats
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Rats, Wistar
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Reactive Oxygen Species / metabolism
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Resveratrol
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Stilbenes / administration & dosage*
Substances
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Antioxidants
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Arsenicals
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Environmental Pollutants
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Oxides
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Reactive Oxygen Species
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Stilbenes
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Glutathione
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Arsenic
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Resveratrol
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Arsenic Trioxide