Experimental tissue damage after subcutaneous injection of water soluble contrast media

Invest Radiol. 1990 Jun;25(6):678-85. doi: 10.1097/00004424-199006000-00011.

Abstract

Various water soluble contrast media (WSCM) were injected subcutaneously into 970 hind feet of 485 rats. Gross morphologic changes were seen after the injection and analyzed as a function of various physicochemical characteristics of WSCM. The WSCM of larger volume, higher osmolality, higher iodine content, and meglumine salts rather than sodium salts caused more severe tissue damage; younger rats showed more severe tissue damage by WSCM of high osmolality.

MeSH terms

  • Animals
  • Contrast Media / administration & dosage
  • Contrast Media / toxicity*
  • Diatrizoate / toxicity
  • Injections, Subcutaneous
  • Iohexol / toxicity
  • Iopamidol / toxicity
  • Iothalamic Acid / toxicity
  • Ioxaglic Acid / toxicity
  • Rats
  • Rats, Inbred Strains
  • Skin / drug effects
  • Skin / pathology*

Substances

  • Contrast Media
  • Diatrizoate
  • Iothalamic Acid
  • Iohexol
  • iopromide
  • ioxitalamic acid
  • Iopamidol
  • Ioxaglic Acid