Methyl - aminolevulinic acid photodynamic therapy and topical tretinoin in a patient with vulvar extramammary Paget's disease

Dermatol Ther. 2013 Mar-Apr;26(2):170-2. doi: 10.1111/j.1529-8019.2013.01546.x.

Abstract

Extramammary Paget's disease is a rare neoplasm of apocrine gland-bearing areas of the skin. The most common site of presentation is the vulva. Surgery is the most frequently reported therapy so far; however, it is invasive and it is complicated by a high rate of recurrence. For this reason, several less-invasive treatments have been recently proposed, including photodynamic therapy. We describe in this article the case of an 84-year-old patient with a noninvasive vulvar extramammary Paget's disease successfully treated with methyl-aminolevulinic acid photodynamic therapy associated with topical tretinoin.

Publication types

  • Case Reports

MeSH terms

  • Administration, Cutaneous
  • Aged, 80 and over
  • Aminolevulinic Acid / administration & dosage
  • Aminolevulinic Acid / analogs & derivatives*
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use
  • Female
  • Humans
  • Paget Disease, Extramammary / drug therapy*
  • Paget Disease, Extramammary / pathology
  • Photochemotherapy / methods*
  • Photosensitizing Agents / administration & dosage
  • Tretinoin / administration & dosage
  • Tretinoin / therapeutic use*
  • Vulvar Neoplasms / drug therapy*
  • Vulvar Neoplasms / pathology

Substances

  • Antineoplastic Agents
  • Photosensitizing Agents
  • Tretinoin
  • methyl 5-aminolevulinate
  • Aminolevulinic Acid