Haemolytic anaemia after oral artemether-lumefantrine treatment in a patient affected by severe imported falciparum malaria

P De Nardo; A Oliva; M L Giancola; P Ghirga; P Mencarini; M Bibas; E Nicastri; A Antinori; A Corpolongo

doi:10.1007/s15010-013-0451-x

Haemolytic anaemia after oral artemether-lumefantrine treatment in a patient affected by severe imported falciparum malaria

Infection. 2013 Aug;41(4):863-5. doi: 10.1007/s15010-013-0451-x. Epub 2013 Apr 4.

Authors

P De Nardo¹, A Oliva, M L Giancola, P Ghirga, P Mencarini, M Bibas, E Nicastri, A Antinori, A Corpolongo

Affiliation

¹ Lazzaro Spallanzani, National Institute for Infectious Diseases-IRCCS, Via Portuense 292, 00179, Rome, Italy. [email protected]

PMID: 23553281
DOI: 10.1007/s15010-013-0451-x

Abstract

Artemisinin and its derivatives are essential components of artemisinin-based combination therapies for treating severe falciparum malaria. In this paper, we describe the occurrence of haemolysis after oral artemether-lumefantrine treatment. To the best of our knowledge, this is the second reported case of a patient affected by severe falciparum malaria with haemolytic anaemia that is likely associated with oral artemether-lumefantrine treatment.

Publication types

Case Reports

MeSH terms

Administration, Oral
Anemia, Hemolytic / chemically induced*
Antimalarials / administration & dosage
Antimalarials / adverse effects*
Artemether, Lumefantrine Drug Combination
Artemisinins / administration & dosage
Artemisinins / adverse effects*
Drug Combinations
Ethanolamines / administration & dosage
Ethanolamines / adverse effects*
Fluorenes / administration & dosage
Fluorenes / adverse effects*
Humans
Malaria, Falciparum / drug therapy*
Male
Middle Aged

Substances

Antimalarials
Artemether, Lumefantrine Drug Combination
Artemisinins
Drug Combinations
Ethanolamines
Fluorenes