Abstract
The cycloaddition of chiral tert-butanesulfinimines with trimethylenemethane is found to give facile access to methylene-pyrrolidines with good yields and diastereoselectivities. The full scope of the cycloaddition is explored, and a range of transformations of the formed methylenepyrrolidines to give a range of functionalized chiral pyrrolidines is presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Butanes / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Cycloaddition Reaction
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Imines / chemistry*
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Methane / analogs & derivatives*
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Methane / chemistry
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Molecular Structure
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Pyrrolidines / chemical synthesis*
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Pyrrolidines / chemistry
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Stereoisomerism
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Sulfonium Compounds / chemistry*
Substances
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Butanes
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Imines
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Pyrrolidines
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Sulfonium Compounds
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sulfinimine
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trimethylenemethane
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Methane