Spontaneous ovarian hyperstimulation syndrome: case report, pathophysiological classification and diagnostic algorithm

Eur J Obstet Gynecol Reprod Biol. 2013 Jul;169(2):143-8. doi: 10.1016/j.ejogrb.2013.03.004. Epub 2013 Apr 3.

Abstract

Spontaneous ovarian hyperstimulation syndrome is an extremely rare condition that occurs in the absence of ovarian hyperstimulation treatment. It can lead to significant morbidity and mortality, and therefore early diagnosis and supportive treatment are essential. We report an affected mother and her daughter with a previously reported heterozygous activating mutation in the FSHR gene. We performed a literature review with particular regard to pathogenesis, with a view to suggesting a pathophysiological classification system and a diagnostic algorithm to assist in the management of this rare condition.

Keywords: FSH receptor; Pathophysiological classification; Spontaneous ovarian hyperstimulation syndrome.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms
  • Female
  • Humans
  • Ovarian Hyperstimulation Syndrome / diagnosis*
  • Ovarian Hyperstimulation Syndrome / etiology*
  • Ovarian Hyperstimulation Syndrome / genetics
  • Pregnancy
  • Pregnancy Complications / diagnosis*
  • Pregnancy Complications / etiology*
  • Pregnancy Complications / genetics
  • Receptors, FSH / genetics
  • Young Adult

Substances

  • Receptors, FSH