Acute pancreatitis caused by bortezomib

Pancreatology. 2013 Mar-Apr;13(2):189-90. doi: 10.1016/j.pan.2013.01.002. Epub 2013 Jan 19.

Abstract

Drug-induced pancreatitis has been reported rarely. Bortezomib is a selective and reversible proteasome inhibitor used for the treatment of patients with multiple myeloma (MM). Recently, one case report about acute pancreatitis (AP) caused by bortezomib was published in the international literature. Herein we report a case of AP in a 67-year-old male on bortezomib therapy. On the fourth day after the first administration of bortezomib, the patient admitted to the hospital with symptoms of AP. The common etiological factors for AP were all excluded. Than the patient was diagnosed as bortezomib-induced pancreatitis.

MeSH terms

  • Aged
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Boronic Acids / adverse effects*
  • Boronic Acids / therapeutic use
  • Bortezomib
  • Dexamethasone / therapeutic use
  • Humans
  • Male
  • Multiple Myeloma / drug therapy
  • Pancreatitis / chemically induced*
  • Pancreatitis / pathology
  • Pyrazines / adverse effects*
  • Pyrazines / therapeutic use

Substances

  • Antineoplastic Agents
  • Boronic Acids
  • Pyrazines
  • Bortezomib
  • Dexamethasone