A novel method to access chiral nonnatural 2,4-disubstituted pyrrolidines from aldehydes and nitroolefins only with an α-substituent

Chem Commun (Camb). 2013 May 18;49(40):4561-3. doi: 10.1039/c3cc40583d. Epub 2013 Apr 8.

Abstract

A series of α-substituted nitroolefins were employed in organocatalytic asymmetric Michael reactions with aldehydes. γ-Nitro carbonyl products were achieved in good yields (up to 86%) with good stereoselectivities (up to 96% ee and 24 : 1 dr). Reduction of the nitro group followed by intramolecular reductive amination successfully afforded various novel optically active 2,4-disubstituted pyrrolidine compounds.

MeSH terms

  • Aldehydes / chemistry*
  • Alkenes / chemistry*
  • Molecular Structure
  • Nitro Compounds / chemistry*
  • Pyrrolidines / chemical synthesis*
  • Pyrrolidines / chemistry

Substances

  • Aldehydes
  • Alkenes
  • Nitro Compounds
  • Pyrrolidines