Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes

J Neuroimmunol. 2013 May 15;258(1-2):85-90. doi: 10.1016/j.jneuroim.2013.02.006. Epub 2013 Apr 5.

Abstract

Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and other inflammatory central nervous system disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / immunology
  • Autoantigens / immunology
  • B-Lymphocytes / immunology*
  • Cell Count
  • Cell Differentiation / immunology
  • ELAV Proteins / immunology
  • Flow Cytometry
  • Humans
  • Immunologic Memory / immunology
  • Paraneoplastic Syndromes / blood
  • Paraneoplastic Syndromes / immunology*
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Autoantibodies
  • Autoantigens
  • ELAV Proteins