Serotonin transporter in attention-deficit hyperactivity disorder--preliminary results from a positron emission tomography study

Linnea Karlsson; Lauri Tuominen; Antti Huotarinen; Sami Leppämäki; Elina Sihvola; Semi Helin; Maria Sipilä; Pekka Tani; Jussi Hirvonen; Jarmo Hietala; Hasse Karlsson

doi:10.1016/j.pscychresns.2013.02.001

Serotonin transporter in attention-deficit hyperactivity disorder--preliminary results from a positron emission tomography study

Psychiatry Res. 2013 May 30;212(2):164-5. doi: 10.1016/j.pscychresns.2013.02.001. Epub 2013 Apr 6.

Authors

Linnea Karlsson¹, Lauri Tuominen, Antti Huotarinen, Sami Leppämäki, Elina Sihvola, Semi Helin, Maria Sipilä, Pekka Tani, Jussi Hirvonen, Jarmo Hietala, Hasse Karlsson

Affiliation

¹ Turku University Hospital, Department of Child Psychiatry, P.O. Box 52, 20521 Turku, Finland. [email protected]

PMID: 23566552
DOI: 10.1016/j.pscychresns.2013.02.001

Abstract

The serotonin transporter (SERT) in attention-deficit hyperactivity disorder (ADHD) patients has not been explored by earlier positron emission tomography (PET) studies. We measured SERT availability in female ADHD patients (n=8) and healthy controls (n=14) with PET and [11C]MADAM as a tracer. No significant group differences in [11C]MADAM binding potential were noted.

MeSH terms

Adult
Attention Deficit Disorder with Hyperactivity / diagnostic imaging
Attention Deficit Disorder with Hyperactivity / metabolism*
Benzylamines / pharmacokinetics
Brain / diagnostic imaging
Brain / metabolism*
Brain / pathology
Carbon Radioisotopes / pharmacokinetics
Female
Humans
Middle Aged
Positron-Emission Tomography
Serotonin Plasma Membrane Transport Proteins / metabolism*
Statistics, Nonparametric
Young Adult

Substances

Benzylamines
Carbon Radioisotopes
N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine
Serotonin Plasma Membrane Transport Proteins