Abstract
Experimental data do not support the idea that excitation-contraction coupling in heart muscle can be explained by a simple calcium-induced calcium release mechanism alone or a simple voltage-dependent calcium release mechanism alone. Our data on excitation-contraction coupling combined with the results of others suggest the need to either develop more complex and more sophisticated single-mechanism models, or to establish dual-control models.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Calcium / metabolism*
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Guinea Pigs
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Humans
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Membrane Potentials
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Microscopy, Fluorescence
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Myocardial Contraction*
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Myocardium / metabolism
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Myocardium / ultrastructure
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Rats
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Sarcoplasmic Reticulum / metabolism
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Sarcoplasmic Reticulum / physiology*
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Sarcoplasmic Reticulum / ultrastructure
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Sodium / metabolism*
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Ventricular Function*