Pd-catalyzed C3-selective arylation of pyridines with phenyl tosylates

Chem Commun (Camb). 2013 May 21;49(41):4634-6. doi: 10.1039/c3cc41066h. Epub 2013 Apr 11.

Abstract

We have discovered that phenyl tosylates can be used to arylate pyridines at the C3-position using a Pd(OAc)2-1,10-phenanthroline catalyst system. We also discovered that the reaction of 4-methylpyridine with naphthyl tosylates occurred on the methyl group instead of at the C3-position.