Abstract
Some new benzenesulfonylthiourea derivatives substituted with phthalazones (2a-q) were synthesized by refluxing the appropriate 4-aryl-1-oxophthalazin-2(1H)yl benzenesulfonamides with isothiocyanate in dry acetone over anhydrous K₂CO₃. All the synthesized compounds were characterized on the basis of IR, (1)H NMR, MS data and elemental analysis. These synthesized compounds (2a-q) at the dose of 20 mg/kg were tested for antihyperglycemic activity in the glucose-fed hyperglycemic normal rat model and among these compounds 2f and 2m showed modest antihyperglycemic activity.
Keywords:
Antihyperglycemic; diabetes; phthalazone; sulfonylthiourea.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzenesulfonates / chemical synthesis*
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Benzenesulfonates / pharmacology
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Blood Glucose / metabolism*
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Drug Design
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Female
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Glucose / administration & dosage
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Hyperglycemia / chemically induced
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Hyperglycemia / drug therapy*
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Hypoglycemic Agents / chemical synthesis*
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Hypoglycemic Agents / pharmacology
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Isothiocyanates / chemistry
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Male
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Phthalazines / chemistry*
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Rats
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Rats, Wistar
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Structure-Activity Relationship
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Thiourea / analogs & derivatives
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Thiourea / chemical synthesis*
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Thiourea / pharmacology
Substances
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Benzenesulfonates
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Blood Glucose
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Hypoglycemic Agents
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Isothiocyanates
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Phthalazines
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isothiocyanic acid
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Thiourea
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Glucose