Acute effects of three club drugs on the striatum of rats: evaluation by quantitative autoradiography with [18F]FDOPA

Chun-Kai Fang; Hong-Wen Chen; Wei-Hsun Wang; Ren-Shen Liu; Jeng-Jong Hwang

doi:10.1016/j.apradiso.2013.03.091

Acute effects of three club drugs on the striatum of rats: evaluation by quantitative autoradiography with [18F]FDOPA

Appl Radiat Isot. 2013 Jul:77:153-9. doi: 10.1016/j.apradiso.2013.03.091. Epub 2013 Apr 2.

Authors

Chun-Kai Fang¹, Hong-Wen Chen, Wei-Hsun Wang, Ren-Shen Liu, Jeng-Jong Hwang

Affiliation

¹ Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan.

PMID: 23587698
DOI: 10.1016/j.apradiso.2013.03.091

Abstract

In this work, we used quantitative autoradiography to study the acute effect of cocaine, methamphetamine, and ketamine on the uptake of [(18)F]FDOPA in the striatum of rats. Drugs were treated 0.5 h before (pre-treated), and 1.5 h after (post-treated) [(18)F]FDOPA injections, rats were then sacrificed at 2 h post [(18)F]FDOPA injections to determine the striatum/frontal cortex binding ratios in the striatum. The ratios were lower in the post-treated groups than those of the pre-treated groups, suggesting a net effect of inhibition of trapping of the tracer. The order of uptake inhibition is: ketamine>methamphetamine>cocaine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autoradiography / methods*
Corpus Striatum / diagnostic imaging
Corpus Striatum / drug effects*
Corpus Striatum / metabolism*
Dihydroxyphenylalanine / analogs & derivatives*
Dihydroxyphenylalanine / pharmacokinetics
Illicit Drugs / toxicity*
Male
Metabolic Clearance Rate
Radionuclide Imaging
Radiopharmaceuticals
Rats
Tissue Distribution

Substances

Illicit Drugs
Radiopharmaceuticals
fluorodopa F 18
Dihydroxyphenylalanine