The integration of T cell migration, differentiation and function

Nat Rev Immunol. 2013 May;13(5):309-20. doi: 10.1038/nri3442. Epub 2013 Apr 19.

Abstract

T cells function locally. Accordingly, T cells' recognition of antigen, their subsequent activation and differentiation, and their role in the processes of infection control, tumour eradication, autoimmunity, allergy and alloreactivity are intrinsically coupled with migration. Recent discoveries revise our understanding of the regulation and patterns of T cell trafficking and reveal limitations in current paradigms. Here, we review classic and emerging concepts, highlight the challenge of integrating new observations with existing T cell classification schemes and summarize the heuristic framework provided by viewing T cell differentiation and function first through the prism of migration.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / immunology
  • Cell Movement / immunology*
  • Humans
  • Immunologic Memory / immunology
  • Lymphocyte Activation / immunology
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / immunology
  • T-Lymphocytes / classification
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • Terminology as Topic