Multicomponent multicatalyst reactions (MC)2R: one-pot synthesis of 3,4-dihydroquinolinones

Org Lett. 2013 May 3;15(9):2128-31. doi: 10.1021/ol4006008. Epub 2013 Apr 19.

Abstract

A Rh/Pd/Cu catalyst system led to an efficient synthesis of dihydroquinolinones in one-pot, two operations. The reaction features the first triple metal-catalyzed transformations in one reaction vessel, without any intermediate workup. The conjugate-addition/amidation/amidation reaction sequence is highly modular, divergent, and practical.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Metals / chemistry*
  • Molecular Structure
  • Quinolones / chemical synthesis*
  • Quinolones / chemistry*

Substances

  • Metals
  • Quinolones