Abstract
The presence of tumor cells with monocytoid morphology in marginal zone lymphoma (MZL) has been described previously. Reactive monocytoid B cells bear a distinct immunophenotype and typically express T-bet, which clearly distinguishes them from nodal marginal zone B cells. The latter are positive for CD27 and negative for T-bet. We analyzed 74 MZLs for the expression of T-bet and correlated these results with the presence of monocytoid morphology. Expression of T-bet correlated with the presence of monocytoid morphology in MZLs. In analogy to reactive monocytoid B lymphocytes, we also found a significantly lower relative amount of intratumoral T lymphocytes in extranodal MZL with monocytoid morphology.
MeSH terms
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Gene Expression
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Humans
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Immunophenotyping
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Lymph Nodes / metabolism
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Lymph Nodes / pathology
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Lymphoma, B-Cell, Marginal Zone / genetics
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Lymphoma, B-Cell, Marginal Zone / immunology
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Lymphoma, B-Cell, Marginal Zone / metabolism*
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Lymphoma, B-Cell, Marginal Zone / pathology*
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Monocytes / metabolism*
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Monocytes / pathology*
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Spleen / metabolism
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Spleen / pathology
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T-Box Domain Proteins / genetics
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T-Box Domain Proteins / metabolism*
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T-Lymphocytes / pathology*
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T-bet Transcription Factor
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Tumor Necrosis Factor Receptor Superfamily, Member 7 / genetics
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Tumor Necrosis Factor Receptor Superfamily, Member 7 / metabolism
Substances
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T-Box Domain Proteins
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T-bet Transcription Factor
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Tumor Necrosis Factor Receptor Superfamily, Member 7