Total synthesis of the marine cyclic depsipeptide viequeamide a

Dongyu Wang; Shanshan Song; Ye Tian; Youjun Xu; Zehong Miao; Ao Zhang

doi:10.1021/np4001027

Total synthesis of the marine cyclic depsipeptide viequeamide a

J Nat Prod. 2013 May 24;76(5):974-8. doi: 10.1021/np4001027. Epub 2013 Apr 22.

Authors

Dongyu Wang¹, Shanshan Song, Ye Tian, Youjun Xu, Zehong Miao, Ao Zhang

Affiliation

¹ School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

PMID: 23607568
DOI: 10.1021/np4001027

Abstract

The first total synthesis of viequeamide A, a natural cyclic depsipeptide isolated from a marine button cyanobacterium, was achieved with the N-Me-Val-Thr peptide bond as the final macrocyclization site. The synthetic product gave nearly identical spectroscopic data to that reported for the natural product.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Cyanobacteria / chemistry*
Depsipeptides / chemical synthesis*
Depsipeptides / chemistry
Depsipeptides / isolation & purification
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Depsipeptides
viequeamide A