Rare, germline mutation of KIT with imatinib-resistant multiple GI stromal tumors and mastocytosis

MeSH terms

• Adult
• Antineoplastic Agents / pharmacology*
• Benzamides / pharmacology*
• Biomarkers, Tumor / analysis
• Drug Resistance, Neoplasm*
• Exons
• Gastrointestinal Neoplasms / complications
• Gastrointestinal Neoplasms / diagnostic imaging
• Gastrointestinal Neoplasms / drug therapy
• Gastrointestinal Neoplasms / genetics*
• Gastrointestinal Neoplasms / surgery
• Gastrointestinal Stromal Tumors / complications
• Gastrointestinal Stromal Tumors / diagnostic imaging
• Gastrointestinal Stromal Tumors / drug therapy
• Gastrointestinal Stromal Tumors / genetics*
• Gastrointestinal Stromal Tumors / surgery
• Germ-Line Mutation*
• Humans
• Imatinib Mesylate
• Immunohistochemistry
• Intestine, Small* / pathology
• Intestine, Small* / surgery
• Male
• Mastocytosis / complications
• Mastocytosis / genetics*
• Piperazines / pharmacology*
• Protein Kinase Inhibitors / pharmacology
• Proto-Oncogene Proteins c-kit / analysis
• Proto-Oncogene Proteins c-kit / genetics*
• Pyrimidines / pharmacology*
• Tomography, X-Ray Computed