Abstract
Studies indicate a close relationship between Yersinia and Crohn's disease in adults. Our study tested 77 colonic specimens from children with Crohn's disease for the presence of Yersinia DNA using a validated polymerase chain reaction (PCR) assay. Control cases included specimens from 45 ulcerative colitis patients and 10 appendicitis patients. The presence of Yersinia in Crohn's specimens was significant compared to the control specimens (9% vs. 0%; p = 0.0055). While our study supports the medical literature, future studies are needed to determine if the relationship between Crohn's disease and Yersinia is an initiating or mediating factor in the pathogenesis of pediatric Crohn's disease.
MeSH terms
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Adolescent
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Bacterial Proteins / genetics
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Case-Control Studies
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Child
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Crohn Disease / microbiology*
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DNA, Bacterial / genetics
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DNA, Bacterial / isolation & purification
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Female
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Genes, Bacterial
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Humans
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Intestinal Mucosa / microbiology
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Male
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Retrospective Studies
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Yersinia / genetics
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Yersinia / isolation & purification*
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Yersinia / pathogenicity*
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Yersinia enterocolitica / genetics
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Yersinia enterocolitica / isolation & purification
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Yersinia enterocolitica / pathogenicity
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Yersinia pseudotuberculosis / genetics
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Yersinia pseudotuberculosis / isolation & purification
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Yersinia pseudotuberculosis / pathogenicity
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Young Adult
Substances
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Bacterial Proteins
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DNA, Bacterial
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YopP protein, Yersinia
Supplementary concepts
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Pediatric Crohn's disease