Abstract
In the search for novel biological agents, a series of new derivatives N-substituted 1,3-benzoxazol-2(3H)-one, 5-chloro-1,3-benzoxazol-2(3H)-one, 6-bromo-1,3-benzoxazol-2(3H)-one were prepared. All of the compounds were characterized by 1H NMR, 13C NMR and ESI MS spectra. Moreover, for compound 1 an Xray structure was determined. All derivatives were tested for antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts. The selected compounds (2-8, 10) were tested for their cytotoxic properties in K562, HeLa and normal cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Benzoxazoles / chemical synthesis*
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Benzoxazoles / pharmacology*
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Cell Survival / drug effects
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / growth & development
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HeLa Cells
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Human Umbilical Vein Endothelial Cells / drug effects
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Humans
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Inhibitory Concentration 50
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K562 Cells
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Spectrometry, Mass, Electrospray Ionization
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Structure-Activity Relationship
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Yeasts / drug effects
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Yeasts / growth & development
Substances
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Anti-Infective Agents
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Antineoplastic Agents
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Benzoxazoles
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benzoxazolone