MicroRNA-323-3p: a new biomarker and potential therapeutic target for rheumatoid arthritis

Rheumatol Int. 2014 May;34(5):721-2. doi: 10.1007/s00296-013-2767-3. Epub 2013 Apr 25.

Abstract

Increased expression of microRNA-323-3p (miR-323-3p) has been demonstrated in rheumatoid arthritis synovial fibroblast. The gene encoding miR-323-3p, which is a biomarker in immune and inflammatory responses, occurs in an miRNA cluster in chromosomal region 14q32.31.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / metabolism
  • Arthritis, Rheumatoid / therapy
  • Disease Models, Animal
  • Genetic Markers
  • Humans
  • Mice
  • Mice, Transgenic
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Genetic Markers
  • MIRN323 microRNA, mouse
  • MicroRNAs
  • Tumor Necrosis Factor-alpha