Febrile seizures in rural Tanzania: hospital-based incidence and clinical characteristics

J Trop Pediatr. 2013 Aug;59(4):298-304. doi: 10.1093/tropej/fmt022. Epub 2013 Apr 24.

Abstract

Objective: Febrile seizures may contribute to epilepsy later in life, but data in sub-Saharan Africa are scarce. We, therefore, conducted a hospital-based study on clinical characteristics of children with febrile seizures.

Methods: Over 2 years, we screened all pediatric admissions of Haydom Lutheran Hospital, northern Tanzania, and recruited 197 children with febrile seizures.

Results: The incidence of febrile seizures was 4% of all admitted children aged <10 years, with a mortality of almost 4%. The peak age at the first febrile seizure was 2 years. One of five children experienced repeated episodes, and the majority of children showed features of complex seizures. Approximately 20% of children had a positive family history of febrile seizures or epilepsy.

Conclusion: Febrile seizures represent a frequent cause for admission of children, bearing a rather high mortality. Most children exhibit complex febrile seizures, which may contribute to the development of epilepsy later in life.

Keywords: complex febrile seizures; concomitant disease; febrile seizures; hospital incidence; lumbar puncture; mortality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Child
  • Cohort Studies
  • Female
  • Hospitalization / statistics & numerical data*
  • Humans
  • Incidence
  • Infant
  • Male
  • Rural Population / statistics & numerical data*
  • Seizures, Febrile / diagnosis
  • Seizures, Febrile / epidemiology*
  • Seizures, Febrile / etiology
  • Severity of Illness Index
  • Socioeconomic Factors
  • Tanzania / epidemiology
  • Treatment Outcome