Abstract
The quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil inhibit the pathogenicity of the Pseudomonas aeruginosa laboratory strains PA01 and PA14; however, there is no report studying the effectiveness of these compounds for clinical isolates. Therefore, the effect of both quorum quenchers on the production of pyocyanin, elastase and alkaline protease of eight clinical strains from children was evaluated. Although both compounds were in general effective for the attenuation of these factors, three strains resistant to C-30 were found. For 5-fluorouracil, PA01 and some clinical isolates showed resistance for at least one phenotype.
© 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / analysis
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Bacterial Proteins / metabolism
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Child
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Drug Resistance, Bacterial
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Endopeptidases / analysis
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Endopeptidases / metabolism
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Fluorouracil / pharmacology*
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Furans / pharmacology*
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Humans
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Pancreatic Elastase / analysis
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Pancreatic Elastase / metabolism
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Pseudomonas Infections / microbiology*
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / isolation & purification
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Pseudomonas aeruginosa / metabolism
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Pyocyanine / analysis
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Pyocyanine / metabolism
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Quorum Sensing / drug effects*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Furans
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furanone C-30
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Pyocyanine
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Endopeptidases
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Pancreatic Elastase
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alkaline protease
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Fluorouracil