Abstract
Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among infants <6 months old infected by PRN-positive or PRN-negative isolates. No major clinical differences were found between the 2 groups.
Keywords:
Bordetella pertussis; acellular vaccines; bacteria; coccobacillus; immunization; pertactin; vaccination; vaccine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Outer Membrane Proteins / metabolism*
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Bacterial Vaccines
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Bordetella pertussis / isolation & purification
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Bordetella pertussis / metabolism
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Bordetella pertussis / pathogenicity*
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Female
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France
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Humans
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Infant
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Male
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Mass Vaccination
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Surveys and Questionnaires
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Virulence
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Virulence Factors, Bordetella / metabolism*
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Whooping Cough / microbiology*
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Whooping Cough / prevention & control
Substances
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Bacterial Outer Membrane Proteins
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Bacterial Vaccines
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Virulence Factors, Bordetella
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pertactin