Synthesis, characterization and cytotoxic activity on breast cancer cells of new half-titanocene derivatives

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3458-62. doi: 10.1016/j.bmcl.2013.03.059. Epub 2013 Mar 26.

Abstract

A series of novel titanocene-complexes has been prepared and evaluated for their growth regulatory effects in MCF7 and SkBr3 breast cancer cells. The capability of some of these compound to elicit relevant repressive effects on cancer cell growth could be taken into account towards novel pharmacological approaches in cancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / therapeutic use
  • Antineoplastic Agents / toxicity
  • Breast Neoplasms / drug therapy
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Drug Screening Assays, Antitumor
  • Female
  • Humans
  • MCF-7 Cells
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / therapeutic use
  • Organometallic Compounds / toxicity

Substances

  • Antineoplastic Agents
  • Organometallic Compounds
  • titanocene