Abstract
A group of counterfeit samples of Viagra and Cialis were screened for their residual solvent content and compared to the content of the genuine products. It was observed that all counterfeit samples had higher residual solvent contents compared to the genuine products. A more diverse range of residual solvents was found as well as higher concentrations. In general these concentrations did not exceed the international imposed maximum limits. Only in a few samples the limits were exceeded. A Projection Pursuit analysis revealed clusters of samples with similar residual solvent content, possibly enabling some future perspectives in forensic research.
Copyright © 2013 Elsevier B.V. All rights reserved.
Publication types
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Comparative Study
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Validation Study
MeSH terms
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Capsules
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Carbolines / analysis*
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Carbolines / chemistry
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Carbolines / standards
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Counterfeit Drugs / analysis*
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Counterfeit Drugs / chemistry
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Gas Chromatography-Mass Spectrometry
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Guidelines as Topic
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Phosphodiesterase 5 Inhibitors / analysis
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Phosphodiesterase 5 Inhibitors / chemistry
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Phosphodiesterase 5 Inhibitors / standards
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Piperazines / analysis*
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Piperazines / chemistry
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Piperazines / standards
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Purines / analysis
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Purines / chemistry
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Purines / standards
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Sildenafil Citrate
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Solvents / analysis*
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Solvents / chemistry
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Sulfones / analysis*
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Sulfones / chemistry
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Sulfones / standards
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Tablets
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Tadalafil
Substances
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Capsules
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Carbolines
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Counterfeit Drugs
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Phosphodiesterase 5 Inhibitors
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Piperazines
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Purines
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Solvents
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Sulfones
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Tablets
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Tadalafil
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Sildenafil Citrate