Abstract
Biophysical understanding of cellular glucose uptake led us to the development of an image-based high-throughput screening system by using a fluorescent glucose bioprobe, GB2. The accuracy, robustness, and practicality of our image-based HTS system were demonstrated through the pilot screening and the subsequent in vitro confirmation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Transport
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Biosensing Techniques / methods
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Cell Line
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Cell Survival
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Fluorescent Dyes / analysis*
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Fluorescent Dyes / metabolism
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Glucose / analysis
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Glucose / metabolism*
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High-Throughput Screening Assays / methods*
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Mice
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Myoblasts / metabolism
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Optical Imaging / methods*