Abstract
A panel of [Au(III)(C^N)(R2NCS2)](+) (HC^N = 2-phenylpyridine) complexes displayed significant deubiquitinases (DUBs) inhibitory activity; one of these complexes showed selective in vitro cytotoxicity towards breast cancer cells correlated to high cellular uptake of gold, and induced cell-cycle arrest, apoptosis, and anti-angiogenic property that could be related to DUB inhibitory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Breast Neoplasms / drug therapy
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Breast Neoplasms / enzymology
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Cell Line, Tumor
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Cysteine Endopeptidases / chemistry
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Cysteine Endopeptidases / metabolism
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Female
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HeLa Cells
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Humans
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Molecular Sequence Data
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Molecular Targeted Therapy
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Neoplasms / drug therapy*
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Neoplasms / enzymology*
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Organogold Compounds / chemistry*
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Organogold Compounds / pharmacology*
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Pyridines / chemistry
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Pyridines / pharmacology
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Ubiquitin Thiolesterase / antagonists & inhibitors
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Ubiquitin Thiolesterase / chemistry
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Ubiquitin Thiolesterase / metabolism
Substances
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Antineoplastic Agents
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Organogold Compounds
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Pyridines
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UCHL1 protein, human
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2-phenylpyridine
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UCHL3 protein, human
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UCHL5 protein, human
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Ubiquitin Thiolesterase
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Cysteine Endopeptidases